Chemokines and the immunological synapse
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چکیده
منابع مشابه
The Immunological Synapse T. Klemmensen: The Immunological Synapse
The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity. A distinct 3-dimensional supramolecular structure at the T cell/APC interface has been suggested to be invo...
متن کاملThe immunological synapse
T-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes place in a specialized cell-cell junction referred to as an immunological synapse. The immunological synapse contains at least two functional domains: a central cluster of engaged antigen receptors and a surrounding ring of adhesion molecules...
متن کاملQuick guide The immunological synapse
Why is it important? The synapse is thought to be the type of intercellular contact through which antigenic peptides — bound to major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells (APCs) — are recognized by the antigen receptors on T lymphocytes. This binding leads to intracellular signals that are critical for lymphocyte activation. It is thought to be e...
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Recent findings on the behaviour of the centrosome at the immunological synapse suggest a critical role for centrosome polarization in controlling the communication between immune cells required to generate an effective immune response. The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in cilia and flagella, and the cellular communica...
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Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required for these processes: for example, the first identification of a protein at the centrosome that regulates its relocation to the plasma membrane...
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ژورنال
عنوان ژورنال: Immunology
سال: 2002
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.2002.01467.x